Bell Performance videos indicate that Mixigo was for regular gas products and works well enough for E-10. It's a 1929 product formulation. Ethanol defense was designed with newer gas...i.e. E-85 in mind. I conducted a little test...running regular 86-7 octane in my 2008 high compression Acura engine. I live in the Chicago air pollution area and have to put up with manipulated gasoline so I'm probably running E-15 or worse all the time I buy premium. I looked and find I can't even get straight gas unless I drive about 50-75 miles. So...I add Ethanol defense at a rate of 1 oz per 10 gallons and find I get better gas mileage using the "regular" 87? octane and Ethanol Defense mix than I get with straight premium even at 93 octane. My pitiful average 15+ mpg went to 17+ mpg avg for whole tanks in mixed local/medium distance driving. It can go down to 16.0 mpg but not much worse. I can push the regular mix to 19+ mpg avg on occasion on the road and even got to 23 MPG once on a fresh charge on the open road at 70 mpg. .Never got that high before and only got it once...at least in the Chicago area. Mostly its 17-18.If I buy non-chicago "Indiana gas"...it's way better...I got 23 mpg on unadultrated premium on the highway in December of 2014.So, in Chicago I used additive with local Shell or BP name brand premium 93 octane to get the 23 mpg for highway driving but it seems to loose its oomph and drops back to 17-18 with local driving. It happens too fast to really justify my using 93 octane with the Ethanol Defender additive. So...I changed to the cheap stuff...I don't feel too bad using low rated cheapo local gas if I have to when run this Ethanol Defense stuff in my 100,000 mile old engine.Hint...get some of those plastic 2-oz energy booster drinks, drink it, pull off the label, relabel the little container and fill it with Ethanol Defense.. The plastic in the bottle is cheap PVC and my studies show its not recommended for gasoline. I take it the PVC is a little soluble in the additive but so far so good. No leakage. The garage was starting to stink a bit from my filling and just from the original 32 oz bottles after opening. I'm careful of filling but it still is a mess. I got a little Justrite gas container to hold the whole 32 bottle. No stink now...but summer has not come. The little PVC energy booster bottle is the best little applicator bottle I've found for measuring and transporting the additive. Fill one and leave it inside the flap of the gas cover all the time. There is room in my MDX gas compartment for one. It fits the spare perfectly and won't stink up the car insides from my little bouts of retrofilling and spilling.When I fill up the car I try and buy a full 20 gallons but I can't so my mixture is always a bit rich...my tank only holds 19 gallons or so. I find the little PVC bottle fits just perfectly into the neck of the gas filler pipe when I want to put it in the tank. It will not slip down into the gas tank when I dump in the contents. The filler pipe has a little spring door in it about 2 inches down and the bottle nestles there perfectly. There is no way that little 3 inch bottle will get stuck. Its easy to insert and pull out by hand after emptying. You probably should discard the PVC bottle every few retrofills. FYI. The Ethanol defender is a good solvent. It does dissolve the finish off my black plastic food grade 2 oz measuring spoon so I don't really know how the PVC energy boost bottle fares. I'll dissect one in a while and report. If it is smooth inside..cool...if it is hazy...not so cool. One thing for sure...I'm saving 10-15 bucks a tank mostly because I use the cheapo gas.Clue...ever hear of Ethyl gasoline....well that used to be what folks called premium. It probably had ethanol in it and some additives. Now it's just advertised as premium octane 91-93. I'll just bet the base fuel on both low octane and high octane starts as the same material...and I'm guessing the ONLY difference is in the additive. So...by putting in these Bell Performance lab products...you are effectively increasing the Octane rating yourself. On premium its probably redundant. It does not make seem to make economic sense to put the additive in high octane fuel except maybe on long highway drives.Oh..I can't figure out how long the stuff lasts in your tank...most vented tanks probably lose part of the high vapor pressure component within a few days....but once the mixture is formed in a full and capped tank chances are there isn't much loss...just don't be opening the tank for a partial fill-up to say half way. I think you'll dilute and facilitate partial high vapor pressure loss from the liquid. Use your additive from the PVC bottle. I suspect venting the tank to the atmosphere by taking off the gas cap liberates the high vapor pressure fraction in the mixture to make a difference over the course of days or weeks. Dealers told my son in law that E-85 for his flex fuel vehicle should be used up within a week because it got "skunky". I'll bet that's true for E-10 and that high octane/E-15? stuff they don't talk about much.